Ampoule Bottle Headspace Gas Analysis and Detection Method

The headspace gas analysis of ampoule bottle (especially the residual oxygen analysis) is related to the stability of quality of powder injection, water injection, IV bottle, oral liquid and other products in shelf life. HGA-01 Headspace Gas Analyzer and its special sampler produced by Labthink (Jinan Labthink Instruments Co., Ltd. www.labthink.com) can solve the problem of detection of residual oxygen content in ampoule bottles conveniently and efficiently, and make the detection of small volume ampoule bottles and other packaging well realized.

Why control headspace residual oxygen in ampoule bottles

Oxygen is the main factor affecting the shelf life of powder injection, water injection, oral liquid and other products. It is found that the shelf life of products can be effectively prolonged or the preservation quality can be improved by controlling the proportion of gas components in the packaging. At present, ampoule bottles are mainly used for the packaging of powder injection, water injection, oral liquid and other products. When filling is completed, a small amount of air will remain in the bottles, so the actual gas composition in the bottles will be different from the expected, which brings difficulties to the analysis of product quality, validity of predicted quality assurance period and rationality of packaging design. HGA-01 Headspace Gas Analyzer produced by Labthink can effectively solve the problem of gas composition analysis in ampoule bottles. Now it has become an important means to test the quality of drug design and one of the important methods to verify the shelf life of products.

Difficulties in ampoule bottles headspace gas analysis and detection

The residual oxygen is the key point of headspace gas analysis and detection, but generally the volume of ampoule bottles commonly used for powder injection, water injection, oral liquid and other products is very small, which means the amount of gas in the headspace of ampoule bottles is small, the general headspace gas analysis equipment cannot carry out the analysis and test of gas collection less than 0.5ml or 0.2ml, it is one of the difficulties for headspace gas analysis and detection of small volume packages such as ampoule bottles.

Choose suitable Classic 650 Headspace Gas Analyzer

At present, most conventional headspace gas analyzers on the market is basically unable to complete the residual oxygen analysis of water injection, powder injection and other drugs. Labthink Classic 650 Headspace Gas Analyzer can well solve the above difficulties through a special sampler, so that headspace gas analysis and detection of small packaging can be realized. HGA-01 Headspace Gas Analyzer has the advantages of desktop and portable equipment, and many other unique advantages. First of all, it can detect the content of oxygen and carbon dioxide at the same time, and the measuring range and precision is the international first-class product level. Secondly, it has automatic and manual sampling methods. The special needle, gasket and filter are equipped to reduce the extraction time and response time, it ensures the real and effective test data. In addition, the instrument is equipped with the current international mainstream gas analysis sensor, which has at least 6 years of working life. The instrument is portable at the same time it has the printing function that the traditional portable equipment does not have, so that it can be conveniently used in various environments for rapid tests.

Summary of ampoule bottles residual oxygen analysis and detection

Through the analysis and detection of headspace oxygen residual in ampoule bottles, we can control the change of gas composition in the packaging of products such as powder injection, water injection and oral liquid more conveniently, accurately and quickly. It provides reference for analysis of product quality, validity of predicted quality assurance period and rationality of packaging design, and it is an indispensable method to strengthen product quality control. HGA-01 Headspace Gas Analyzer is a practical and reliable instrument which is suitable for pharmaceutical companies for residual oxygen analysis and quality control.