The headspace gas analysis of Large Volume Parenteral solution (LVP) (especially the detection and analysis of residual oxygen in LVP) is related to the product quality in the shelf life. Labthink HGA-01 Headspace Gas Analyzer and its special sampler can realize the analysis and detection of residual oxygen detection of LVP package (LVP solution bottle, LVP solution bag) conveniently, economically.

Oxygen is the main factor affecting the shelf life of LVP solution. It is found that the shelf life of products can be effectively prolonged or the preservation quality can be improved by controlling the proportion of gas components in LVP solution bottles and LVP solution bags. In order to minimize the content of specific gas in large infusion package, Modified Atmosphere Packaging (MAP) and Controlled Atmosphere Packaging (CAP) have been widely used in the LVP production. The inert gas that plays a key role in prolonging the shelf life of products is mainly composed of nitrogen or nitrogen and carbon dioxide with stable properties. However, there are always certain gases in the LVP packaging that cannot be eliminate such as oxygen and other gases. The gas composition changes with the storage time. It can be seen that no matter which packaging form is adopted, it is always difficult for us to completely control the gas composition inside the packaging, which brings difficulties to the analysis of product quality, validity of shelf life prediction and the rationality in packaging design. HGA-01 Headspace Gas Analyzer can effectively solve this problem.

Labthink HGA-01 Headspace Gas Analyzer can well solve the above difficulties through a special sampler, so that headspace gas analysis and detection of small packaging can be realized. HGA-01 Headspace Gas Analyzer has the advantages of desktop and portable equipment, and has many unique advantages. First of all, its measuring range and precision is the international first-class level. Secondly, there are two injection methods, automatic injection and manual injection, which can detect the content of oxygen and carbon dioxide at the same time. A special needle, gasket and filter are equipped, the extraction time and response time are also improved to the greatest extent, ensures the accuracy and effectiveness of test data. In addition, the instrument is equipped with the current international mainstream gas analysing sensor, which can works normal for at least 6 years. The instrument is faciliated with the advantages of both desktop type and portable type, it also has the printing function that traditional portable instruments don’t have, so that it can be easily used in various environments and rapid test of samples.

By analyzing the headspace gas residual oxygen in LVP bottles and LVP bags, we can monitor the change of gas composition in the packaging in a more convenient, accurate and quick fashion. It is an important data support for the analysis of product quality, shelf life validity and packaging design. It is an indispensable detection method to strengthen product quality control. HGA-01 Headspace Gas Analyzer is practical and reliable, combining with the specially designed sampler, it is suitable for residual oxygen analysis and quality control for pharmaceutical companies.

For more details on headspace gas analysis (residual oxygen analyzer) visit www.labthink.com.

Alternative product